ABSTRACT
This research was done to investigate some of the risk factors of chronic renal failure among adult Yemeni patients. A case-control study of two groups, each containing 140 patients, was designed. Cases were the patients with chronic renal failure in the dialysis center of Al-Thawra Modern General Hospital in Sana'a. The controls were selected from other departments: general surgery, orthopedics and gynecology. The groups were matched for age, sex and residence. Risk factors studied included previous renal calculi, urinary tract infections, diabetes mellitus, hypertension, prostatic enlargement, malaria, tuberculosis, family history, analgesic abuse and Khat chewing. Mean age of cases was 38.6 +/- 13.9 years and that of the controls was 39.7 +/- 12.6 years. Renal calculi were found to be the most common risk factor for chronic renal failure in Yemen, with odds ratio of 11.23. The second risk factor was hypertension with odds ratio of 8.33. Third was a history of urinary tract infection with odds ratio of 4.04. The family history of hereditary diseases was the fourth risk factor with odds ratio of 3.24, and last was analgesic abuse with odds ratio of 2.05. The other studied factors were found to be of no significance in relation to chronic renal failure. Renal calculi were the leading risk factor for chronic renal failure